The Nullarbor sub-region of the Rangelands is located in the south-east of WA and comprises 70 percent of the Nullarbor  and the whole of the Hampton IBRA bioregions.

It is dominated by broad, gently undulating limestone plains with predominantly chenopod vegetation, with a number of bluebush and saltbush species, sometimes with a scattered overstorey of western myall or mulga. The plains are progressively more wooded in the northern and western parts. Perennial grasses are common where fires have removed the chenopod vegetation.

The climate of the Nullarbor sub-region is arid to semiarid.

Pastoralism is the predominant land use within the WA area, and there are no major population centres in the bioregion. Yalata is one of the smaller centres.